1 in 20 children worldwide is born with a birth defect or genetic disease. Children’s Medical Research Institute (CMRI) is dedicated to advancing the treatment and prevention of childhood diseases, so every child has the opportunity for a healthy start to life. CMRI pioneered microsurgery, immunisations against lethal childhood illnesses and care for premature babies, all of which has improved the lives of countless Australian children over the last 58 years. Today, CMRI is the site of world-leading research in areas such as cancer, neurobiology, embryology and gene therapy. On the first Friday in August each year workplaces, schools and streets become a sea of denim in a united stance against childhood disease. Every dollar raised on the day helps scientists at Children’s Medical Research Institute discover treatments and cures, to give every child the opportunity to live a long and healthy life.